Despite the continuous challenges and questions that skin cancer poses to dermatologists, the therapeutic outlook appears to be improving. Over the last several years, new research has delved into the genetic factors of melanoma and clarified links between UV exposure and melanoma and other skin cancers. In addition, several newly approved and investigational therapies are targeting specific pathways and offering patients more options for managing disease. As we look to 2014 and consider the future of skin cancer research and treatment, it is important to keep informed regarding the latest therapeutic trends while never losing sight of boosting awareness for prevention efforts. Ahead are some trends in research and treatment that are worth noting.